Integrative Psychiatry Psychopharmacology

Recommended articles, web sites & books for information about recent research on dietary supplements and mental health:

Omega-3 fatty acids:

Video clips from the 1998 NIH Workshop on Essential Fatty Acids (EFA's) in Psychiatric Disorders (needs fast internet connection):

http://videocast.nih.gov/ram/omega1.ram

http://videocast.nih.gov/ram/omega2.ram

http://videocast.nih.gov/ram/omega3.ram

http://videocast.nih.gov/ram/omega4.ram

http://videocast.nih.gov/ram/omega5.ram

http://videocast.nih.gov/ram/omega6.ram

http://videocast.nih.gov/ram/omega7.ram

Omega-3 Figures:
Essential fatty acid (EFA) Books:

Scientific Articles (full text):
- Theory of Omega-3 activity in depression PDF
- Omega-3 in schizophrenia
- Omega-3 treatment of depression in pregnancy PDF
- Omega-3 and risk of postpartum depression PDF
- Omega-3 treatment of borderline personality disorder PDF
- Omega-2 treatment of bipolar disorder PDF
- Fatty acid deficiency in bipolar mania PDF
- Pure DHA does NOT work in major depression (you need EPA also) PDF
- Essential fatty acids and depression in the elderly PDF
- Omega-3 in refractory depression PDF PDF2 PDF3
- Fish consumption & postpartum depression PDF
- Fish oil and rheumatoid arthritis PDF
- Fish oil and inflammatory bowel disease PDF
- Fish and the risk of dementia PDF
- Fish oil in asthma PDF
- Fish oil reduced stroke in men PDF
- Fish oil reduces sudden death PDF
- Omega-3 may reduce coronary heart disease and death in elderly PDF
- Omega-3 and aggression PDF PDF2
- Omega-3 in depression & heart disease PDF
- DHA and aggression PDF
- DHA & violence PDF
- Essential fatty acids in alcoholics PDF
- Fish consumption & suicidality PDF
- Fatty acid supplementation in monkeys PDF
- Effects of supplements in prisoners PDF
- Omeag-3 inhibition of PKC PDF
- Omega-3 in depression & heart disease PDF
- Omega-3 in health & disease PDF
- Omega-3 in dyslexia PDF Omega-3 in ADHD PDF
Other omega-3 sites and references:
- NIAAA EFA
- Polyunsaturated Lipid Function Interest Group
- NIH Office of Dietary Supplements
- iHerb.com
- No depression in Iceland Amer J Psychiat PDF

Omega-3 Sources (a clean product with no fishy taste):

NOTE: Essential fatty acids (EFAs) are easily oxidized and can increase blood levels of harmful lipid peroxides! (Meydani, 1996) Oxidative stress may be already be present in mental illnesses resulting in depletion of membrane fatty acids (PubMed). Neuroleptics also increase oxidative stress. Supplementary vitamins C (up to 2000 mg) and E (up to 1200 mg; natural works better see PDF) are necessary for individuals taking dietary EFAs. For information about the adverse health consequences of trans (partially hydrogenated) fats, see Dr. Mary Enig's site.

Other Nutrients:

Folic acid, depression & dementia PDF
Brain Nutrients PDF

Other Mood Stabilizers:

Treatment of women with bipolar disorder with verapamil (Wisner et al., 2002)* Full text PDF

* important finding!

St. Johns Wort:

Interaction of herbs with other medicines: The example of St John’s Wort. In: Dietary Supplements of Plant Origin: A Nutritional and Health Approach PDF Amozon.com
New positive clinical trial from France PDF
NIH Study published in April 2002 JAMA PDF
Letter to the JAMA editor regarding faulty NIH study (July, 2002)
CNS Spectrums full text article on Herb/Drug Interactions
Interaction with cyclosporin PDF
Comparison with imipramine PDF
ESCOP Review PDF
Activation of pregnane X receptor PDF
Press Conference on Pfizer study in JAMA PDF; American Botanical Council press release; Council for Responsible Nutrition media briefing, fact sheet
HerbMed
Psychiatric News
Psychosomatic Medicine Paper (full text)
Psychiatric Times
PubMed-1 PubMed-2 PubMed-3
Letter to Editor of JAMA regarding faulty Pfizer study
Figures:
- Mechanism
- NIH Trial
- Herb-Drug interactions
- SJW and indinavir
- SJW and cyclosporin